“Functional HepaRG Cells: A breakthrough breakthrough in 3-R research?”
André Guillouzo
University University of Rennes 1and Inserm U620
PDF: download this presentation (2 MB)

“Hepatocyte in vitro gene expression systems: what is the reason for differences between in vivo and and in vitro systems?”
Markus Schug, Dipl. Pharm.
Leibniz Research Centre for Working Environment and Human Factors (IfADo)
PDF: download this presentation (292 kb)

“Non-genotoxic hepatocarcinogens specifically target mitochondria and gap junctions”
Tatyana Doktorova PhD student
Vrije Universiteit Brussel
Promotors: Prof. Dr. Vera Rogiers, Prof. Dr. Tamara Vanhaecke, Dr. Mathieu Vinken
PDF: download this presentation (416 kb)

“Cytotoxic and genotoxic effects of two heterocyclic amines in functional human hepatoma HepaRG cells”
Julie Dumont 1, Rozenn Jossé 1, Valérie Fessard 2, André Guillouzo 1
1 – Inserm U620 , Rennes 1 University, Rennes, France 2 – AFSSA, Unit of genetic toxicology of food contaminants, Fougères, France
PDF: download this presentation (592 kb)

“Markers of proliferation and differentiation in human keratinocyte models”
Yves Poumay
Cell & Tissue Laboratory – URPHYM
University of Namur (Facultés Universitaires Notre-Dame de la Paix) Namur, Belgium
PDF: download this presentation (5.8 MB)

“MicroRNAs: novel regulators in skin research”
Eniko Sonkoly, Andor Pivarcsi
KI, Department of Medicine, Unit of Dermatology and Venerology
PDF: download this presentation (1.1 MB)

“Use of gene silencing in skin models”
Michael Mildner
PDF: download this presentation (4.3 MB)

“Safety aspects of skin penetration of nanoparticles in topically applied cosmetics / pharmaceuticals”
A. Patzelt, H. Richter, W. Sterry, J. Lademann
Center of Experimental and Applied Cutaneous Physiology (CCP)
PDF: download this presentation (2.8 MB)

“Nanoparticle induced pulmonary toxicity”
N.J. Guppy, Institute of Cellular and Molecular Science, QMUL, London, UK
Experimental Toxicology and Ecology, BASF SE, Ludwigshafen, Germany
PDF: download this presentation (1.2 MB)

“Toxicological Studies Of Poly (Anyhydride) Nanoparticles For Oral Drug Delivery”
Patricia Ojer Ojer, Dr. Juan Manuel Irache1, Dra. Adela López de Cerain2
Department of Pharmacy and Pharmaceutical Technology1 & Department of Nutrition and Food Sciences, Physiology and Toxicology2 University of Navarra
PDF: download this presentation (1.2 MB)

“Important issues in immunotoxicity testing of chemicals”
Pr Marc Pallardy
Toxicologie and INSERM UMR-S 749, Faculté de Pharmacie, Châtenay-Malabry, France
PDF: download this presentation (2.6 MB)

“Development Of Iv Vitro Strategies For Studying T-Cell Mediated To Immunological Reactions To Drugs”
Enrique Gomez
Research Laboratory Fundacion IMABIS-Carlos Haya Hospital Málaga, Spain
PDF: download this presentation (2.1 MB)

“In-vitro quantitation of sensitizing potential”
Reinhard Wanner
Institute of Clinical Pharmacology and Toxicology Charité, Berlin, Germany
PDF: download this presentation (1.6 MB)

“Reactivity studies to complement the development of alternative methods for the prediction of skin sensitization: the case of formaldehyde and formaldehyde releasers”
M. Kireche, E. Giménez-Arnau, J.P. Lepoittevin
Institut de Chimie de Strasbourg UniversitéLouisPasteur-CNRS Université Louis Pasteur-CNRS Laboratoire de Dermatochimie Strasbourg, France
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“In vitro differentiation of skin sensitizers by cell signaling pathways”
Lydia-Mareen Koeper,
Bayer HealthCare AG, Toxicology
PDF: download this presentation (968 kb)

“Identification of cell responses induced by a sensitizer in a”
Aurélie Frankart, S. Lambert, A. Coquette, K. Schroeder and Prof. Yves Poumay
PDF: download this presentation (1.5 MB)

“About Pipelines and Shifting paradigms: biopharmaceuticals versus low molecular weight drugs”
Prof. Dr. Daan, J.A. Crommelin,
Scientific Director TI Pharma, a Public Private Partnership, Leiden and Dept. Pharmaceutics, UIPS, UU
PDF: download this presentation (2 MB)

“Prednisolone-treatment induces hepatic insulin resistance in C57Bl/6J mice, measured by a newly develobody glucose test”
Anke Laskewitz
Lab pediatrics Center for liver, digestive and metabolic diseases University medical center Groningen The Netherlands
PDF: download this presentation (676 kb)

“A suitable delivery system is key in the concept of siRNA-mediated treatment”
R. Vandenbroucke
Laboratory of General Biochemistry and Physical Pharmacy
Ghent Research Group on Nanomedicines (GRGN)
Department of Pharmaceutics Ghent University, Belgium
PDF: download this presentation (2.9 MB)

“Molecular imaging in vitro and in vivo”
Tony Lahoutte, MD PhD
Free University Brussels
PDF: download this presentation (1.9 MB)

“An alternative method in (live) cell sampling”
Renate Burgemeister
Laser Microdissection from Carl Zeiss
PDF: download this presentation (11.3 MB)

“COMICS: developing high throughput comet assays for DNA damage and DNA repair”
Amaya Azqueta
on behalf of COMICS partners Department of Nutrition University of Oslo
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“Use of flow-based assays to monitor drugs with antithrombotic, anticoagulant or anti-inflammatory potential”
J. Heemskerk, J. Cosemans
Dept. of Biochemistry Cardiovascular Research Institute Maastricht (CARIM) Maastricht University Medical Centre+, The Netherlands
PDF: download this presentation (2.6 MB)

“Confrontation cultures of embryonic stem cell-derived embryoid bodies and multicellular tumour spheroids: a novel in vitro model for the study of tumour- induced angiogenesis”
N. Milosevic1, Finkensieper2, M. Hannig2, M. Wartenberg2, H. Sauer1
1 Department of Physiology, University of Giessen, Germany
2 Department of Internal Medicine I, University of Jena,Germany
PDF: download this presentation (110 kb)

“Organotypic in vitro skin cancer model”
Suzan Commandeur, MSc
Department of Dermatology, Leids Universitair Medisch Centrum
PDF: download this presentation (4.4 MB)

“Evaluation of toxicological effects of POPs using primary fish cell cultures”
Liv Søfteland, Invar Eide and Pål A. Olsvik
National Institute of Nutrition and Seafood Research
PDF: download this presentation (2.3 MB)

“Free Concentrations in In Vitro Cytotoxicity Assays”
Nynke Kramer, Bas Blaauboer and Joop Hermens
Institute for Risk Assessment Sciences, Division Toxicology, Universiteit Utrecht
PDF: download this presentation (2.6 MB)

“A Cell-Basec Assay For The Detection Of A Potent Algal Neurotoxin In Biological Matrices”
Mirella Bellocci
Università di Modena e Reggio Emilia, Modena, Italy
PDF: download this presentation (1 MB)

“Regulatory Acceptance and Use of in vitro Methods for Non-Clinical Testing of Human Medicinal Products”
Dr. Sonja Beken
Non-Clinical Assessor, Registration Department
Federal Agency for Medicines and Health Products (FAMHP)
PDF: download this presentation (940 kb)

“Validation and Regulatory Acceptance”
Susanne N. Boehn
Laboratory for Alternative Methods Experimental Toxicology and Ecology, BASF SE, Ludwigshafen, Germany
PDF: download this presentation (104 kb)