1-3 March marked the official kick-off of the €50 million European Commission-COLIPA ‘Safety Evaluation Ultimately Replacing Animal Testing’ (SEURAT) programme aimed at replacement of current repeated dose systemic toxicity testing in human safety assessment. The meeting brought together the coordinators of the seven new large-scale and projects, as well as the leaders of ongoing projects funded under the health theme of the 6th and 7th EU Research Framework Programmes.